Proteomics

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Mass spectrum data for the manuscript “oocyte-derived microvilli control female fertility by optimizing the ovarian follicle selection in mice”


ABSTRACT: To clarify our hypothesis and investigate the functional role of Oo-Mv in folliculogenesis, we isolated the ZP containing Oo-Mv from oocytes and performed mass spectrometry (MS) analysis to identify potential regulators of the formation of Oo-Mv.

ORGANISM(S): Mus Musculus

SUBMITTER: Hua Zhang  

PROVIDER: PXD024931 | iProX | Tue Mar 23 00:00:00 GMT 2021

REPOSITORIES: iProX

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Publications

Oocyte-derived microvilli control female fertility by optimizing ovarian follicle selection in mice.

Zhang Yan Y   Wang Ye Y   Feng Xie'an X   Zhang Shuo S   Xu Xueqiang X   Li Lingyu L   Niu Shudong S   Bo Yingnan Y   Wang Chao C   Li Zhen Z   Xia Guoliang G   Zhang Hua H  

Nature communications 20210505 1


Crosstalk between oocytes and surrounding somatic cells is crucial for mammalian oogenesis, but the structural mechanisms on oocytes to control female reproduction remain unknown. Here we combine endogenous-fluorescent tracing mouse models with a high-resolution live-cell imaging system to characterize oocyte-derived mushroom-like microvilli (Oo-Mvi), which mediate germ-somatic communication in mice. We perform 3D live-cell imaging to show that Oo-Mvi exhibit cellular characteristics that fit an  ...[more]

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