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Molecular characterization of advanced colorectal cancer using serum proteomics and metabolomics

ABSTRACT: To comprehensively reveal molecular characterization of advanced CRC, we applied integrated proteomic and metabolomic analyses on serum samples from 20 patients with CRC at stage III or IV. Methods In the present study, we took advantage of nanoscale liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (nanoLC/Q-TOF-MS/MS) and ultraperformance LC/Q-TOF-MS/MS technologies.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhi Zheng

PROVIDER: PXD025041 | iProX | Mon Mar 29 00:00:00 BST 2021

REPOSITORIES: iProX

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Correlation Analysis Between Trace Elements and Colorectal Cancer Metabolism by Integrated Serum Proteome and Metabolome.

Zheng Zhi Z Wei Qingfeng Q Wan Xianghui X Zhong Xiaoming X Liu Lijuan L Zeng Jiquan J Mao Lihua L Han Xiaojian X Tou Fangfang F Rao Jun J

Frontiers in immunology 20220602

Colorectal cancer (CRC) is currently the third most common cancer with a high mortality rate. The underlying molecular mechanism of CRC, especially advanced CRC, remains poorly understood, resulting in few available therapeutic plans. To expand our knowledge of the molecular characteristics of advanced CRC and explore possible new therapeutic strategies, we herein conducted integrated proteomics and metabolomics analyses of 40 serum samples collected from 20 advanced CRC patients before and afte ...[more]

PMID: 35720415

Publication: 1/2

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