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Protein interaction network reveals the biofunctional difference between vegetative cell and heterocyst in multicellular cyanobacteria

ABSTRACT: Protein interaction network reveals the biofunctional difference between vegetative cell and heterocyst in multicellular cyanobacteria

ORGANISM(S): Nostoc Sp. Pcc 7120 = Fachb-418

SUBMITTER: Cuihong Wan

PROVIDER: PXD025312 | iProX | Tue Apr 26 00:00:00 BST 2022

REPOSITORIES: iProX

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Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp.

Xu Chen C Wang Bing B Heng Hailu H Huang Jiangmei J Wan Cuihong C

Molecular & cellular proteomics : MCP 20220311 4

The filamentous cyanobacterium Anabaena sp. PCC 7120 can differentiate into heterocysts to fix atmospheric nitrogen. During cell differentiation, cellular morphology and gene expression undergo a series of significant changes. To uncover the mechanisms responsible for these alterations, we built protein-protein interaction (PPI) networks for these two cell types by cofractionation coupled with mass spectrometry. We predicted 280 and 215 protein complexes, with 6322 and 2791 high-confidence PPIs ...[more]

PMID: 35288331

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