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Rat heterotopic ossification model proteome

ABSTRACT: The mechanism of heterotopic ossification remains largely unclarified. in this project, we administrated Achilles tenotomy (AT) and partial Achilles tenotomy (PAT) to rat models to simulate the varied size of ectopic bone we observed in the clinical courses. Then we applied Data-independent acquisition (DIA) proteomic strategy to identify the proteins and signaling pathways associated with the progress of heterotopic ossification and propagation of the ectopic bone mass.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Biao Zhong

PROVIDER: PXD025678 | iProX | Wed Apr 28 00:00:00 BST 2021

REPOSITORIES: iProX

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Comparative proteomic analysis identifies differentially expressed proteins and reveals potential mechanisms of traumatic heterotopic ossification progression.

Wei Zhenyuan Z Guo Shang S Wang Hongwei H Zhao Yang Y Yan Jiren J Zhang Chi C Zhong Biao B

Journal of orthopaedic translation 20220514

<h4>Background</h4>Traumatic Heterotopic Ossification (tHO) is one of complications of elbow fractures to the detriment of patients' rehabilitation, and the severity of tHO corresponds to the size of ectopic bone. It has yet to be elucidated which proteins and pathways underlying the progression of tHO, and biomarkers to predict the severity of tHO at early stage of the disease also need further investigation.<h4>Methods</h4>In this study, a new rat model with distinct volume of ectopic bone was ...[more]

PMID: 35615641

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