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Protemics of Mettl3-deficient NK cells

ABSTRACT: With mass spectrometry， we aim to find the differentially expressed proteins in Mettl3-deficient NK cells

ORGANISM(S): Mus Musculus

SUBMITTER: Zhigang Tian

PROVIDER: PXD025823 | iProX | Tue Jul 20 00:00:00 BST 2021

REPOSITORIES: iProX

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METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells.

Song Hao H Song Jiaxi J Cheng Ming M Zheng Meijuan M Wang Tian T Tian Sha S Flavell Richard A RA Zhu Shu S Li Hua-Bing HB Ding Chen C Wei Haiming H Sun Rui R Peng Hui H Tian Zhigang Z

Nature communications 20210917 1

Natural killer (NK) cells exert critical roles in anti-tumor immunity but how their functions are regulated by epitranscriptional modification (e.g., N6-methyladenosine (m6A) methylation) is unclear. Here we report decreased expression of the m6A "writer" METTL3 in tumor-infiltrating NK cells, and a positive correlation between protein expression levels of METTL3 and effector molecules in NK cells. Deletion of Mettl3 in NK cells alters the homeostasis of NK cells ...[more]

PMID: 34535671

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