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Asymmetric dimethylarginine proteome in chronic pancreatitis

ABSTRACT: The roles of protein arginine methylation in the pathongenesis of chronic pancreatitis still remains poorly understood. In this study, we performed a proteomic identification of ADMA (asymmetric dimethylarginine)-containing proteins in clinical tissues collected from chronic pancreatitis patients using affinity purification combined with LC-MS/MS.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chaochao Tan

PROVIDER: PXD026106 | iProX | Thu May 20 00:00:00 BST 2021

REPOSITORIES: iProX

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Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis.

Tan Chaochao C Xiao Yan Y Huang Xiangping X Wu Ling L Huang Ying Y

Journal of inflammation research 20211224

<h4>Objective</h4>The pathophysiological mechanisms of chronic pancreatitis (CP) still remain poorly understood. In this study, we aimed to characterize asymmetric dimethylarginine (ADMA)-containing proteins in pancreatic tissues and its relationship with CP pathogenesis.<h4>Methods</h4>Totally 36 patients with CP were enrolled in this study. Seven other cholangiocarcinoma patients without pancreas involvements or patients with benign pancreatic tumors were included as the control group. Total p ...[more]

PMID: 34992424

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