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Striatal proteomics of CMS-treated rats

ABSTRACT: We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the striatal were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jian Zhou

PROVIDER: PXD026107 | iProX | Wed May 19 00:00:00 BST 2021

REPOSITORIES: iProX

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Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum.

Cai Xiao X Yang Chen C Chen Jin J Gong Weibo W Yi Faping F Liao Wei W Huang Rongzhong R Xie Liang L Zhou Jian J

Frontiers in molecular biosciences 20211005

Chronic stress is a key factor for the onset of anxiety and depression disorders. However, the stress-induced common and unique molecular basis of the two psychiatric disorders is not fully known and still needs to be explored. Previously, we employed a chronic mild stress (CMS) procedure to induce a rat model including depression-susceptible (Dep-Sus), anxiety-susceptible (Anx-Sus), and insusceptible (Insus) cohorts. In this work, we continuously analyze the striatal proteomes of the three stre ...[more]

PMID: 34676246

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