Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Duanqing Pei
PROVIDER: PXD026208 | iProX | Sun May 23 00:00:00 BST 2021
REPOSITORIES: iProX
Nature communications 20210702 1
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms microscopic condensates in nuclei through a C-terminal intrinsically disordered region (IDR) rich in tyrosine, which, once mutated, no longer form condensates nor rescue SS18<sup>-/-</sup> defect in PS ...[more]