Proteomics

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Plasma proteome profiling of patients with in-stent restenosis by tandem mass tag-based quantitative proteomics approach


ABSTRACT: Analysis of plasma proteins in patients with in-stent restenosis by tandem mass tag-based quantitative proteomics

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhixiong Zhong  

PROVIDER: PXD026890 | iProX | Thu Jun 24 00:00:00 BST 2021

REPOSITORIES: iProX

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Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach.

Hou Jingyuan J   Deng Qiaoting Q   Liu Sudong S   Qiu Xiaohong X   Deng Xunwei X   Zhong Wei W   Zhong Zhixiong Z  

Frontiers in cardiovascular medicine 20220221


<h4>Background</h4>Despite the widespread application of new drug-eluting stents, a considerable portion of patients experience in-stent restenosis (ISR). To date, the pathophysiologic mechanisms of ISR remain poorly understood.<h4>Methods</h4>In this study, we collected plasma samples from ISR patients (<i>n</i> = 29) and non-ISR patients (<i>n</i> = 36) after drug-eluting stent implantation, as well as from healthy controls (HCs) (<i>n</i> = 32). Our goal was to investigate differences in plas  ...[more]

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