A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Minjia Tan
PROVIDER: PXD026892 | iProX | Wed Jun 23 00:00:00 BST 2021
REPOSITORIES: iProX
Publications
A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies.
Liu Zhiwei Z Liu Yingluo Y Qian Lili L Jiang Shangwen S Gai Xiameng X Ye Shu S Chen Yuehong Y Wang Xiaomin X Zhai Linhui L Xu Jun J Pu Congying C Li Jing J He Fuchu F Huang Min M Tan Minjia M
Molecular cell 20210809 19
KRAS mutant cancer, characterized by the activation of a plethora of phosphorylation signaling pathways, remains a major challenge for cancer therapy. Despite recent advancements, a comprehensive profile of the proteome and phosphoproteome is lacking. This study provides a proteomic and phosphoproteomic landscape of 43 KRAS mutant cancer cell lines across different tissue origins. By integrating transcriptomics, proteomics, and phosphoproteomics, we identify three subsets with distinct biologica ...[more]
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