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DIA proteomics of preeclampsia placental tissues

ABSTRACT: Preeclampsia (PE) has become severe diseases that endangers the safety of mothers and fetuses worldwide.More studies on novel biomarkers for PE are inevitable. Data-independent acquisition proteomics, with five biological replicates, was used to investigate the protein expression profiles from placental tissues.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ruiman Li

PROVIDER: PXD027276 | iProX | Wed Jul 14 00:00:00 BST 2021

REPOSITORIES: iProX

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Screening of differentially expressed proteins in placentas from patients with late-onset preeclampsia.

He Andong A Wang Jingyun J Yang Xiaofeng X Liu Jia J Yang Xuesong X Wang Guang G Li Ruiman R

Proteomics. Clinical applications 20211110 2

<h4>Purpose</h4>Preeclampsia (PE) is a severe disease that endangers the safety of mothers and fetuses worldwide. In the absence of specific treatments, more studies on novel predictive and diagnostic biomarkers for PE are required.<h4>Experimental design</h4>Data-independent acquisition proteomics, with five biological replicates, was used to investigate the protein expression profiles of placental tissues from patients with PE and normal pregnant women.<h4>Results</h4>In total, 52 differential ...[more]

PMID: 34704665

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FOXP2 expression was decreased in placental tissue sample of patients with preeclampsia compared with healthy pregnant women

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