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Proteomics of Vitreous Humor Reveals Upstream Regulators of Proliferative Diabetic Retinopathy

ABSTRACT: To investigate the key regulators of the disease by comparing the abundance of vitreous proteins between the patients with proliferative diabetic retinopathy (PDR) and the controls with idiopathic epiretinal membrane (iERM).

ORGANISM(S): Homo Sapiens

SUBMITTER: Siyan Li

PROVIDER: PXD027556 | iProX | Mon Jul 26 00:00:00 BST 2021

REPOSITORIES: iProX

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Proteomics of Vitreous Humor Reveals PPARA, RXR, and LXR Are Possible Upstream Regulators of Proliferative Diabetic Retinopathy.

Li Siyan S Jin Enzhong E Shi Xuan X Cai Yi Y Zhang Hui H Zhao Mingwei M

Frontiers in medicine 20210817

<b>Purpose:</b> To investigate the key regulators of the disease by comparing the abundance of vitreous proteins between the patients with proliferative diabetic retinopathy (PDR) and the controls with idiopathic epiretinal membrane (iERM). <b>Methods:</b> Vitreous humor (VH) samples were derived from patients with PDR or iERM through the pars plana vitrectomy. The VH proteins were identified by liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. MaxQuant software and Metascape w ...[more]

PMID: 34485353

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