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Urinary proteome of ApoE knockout mouse

ABSTRACT: In this study, ApoE-/- mice induced by a high-fat diet for 5 months were used to construct an animal model of atherosclerosis. Urine samples from the experimental group and control group, which were C57BL/6 mice fed a normal diet, were collected at seven time points.

ORGANISM(S): Mus Musculus

SUBMITTER: Youhe Gao

PROVIDER: PXD027610 | iProX | Wed Jul 28 00:00:00 BST 2021

REPOSITORIES: iProX

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Changes to Urinary Proteome in High-Fat-Diet <i>ApoE</i><sup>-/-</sup> Mice.

Hua Yuanrui Y Meng Wenshu W Wei Jing J Liu Yongtao Y Gao Youhe Y

Biomolecules 20221026 11

Cardiovascular disease is currently the leading cause of death worldwide. Atherosclerosis is an important pathological basis of cardiovascular disease, and its early diagnosis is of great significance. Urine bears no need nor mechanism to be stable, so it accumulates many small changes and is therefore a good source of biomarkers in the early stages of disease. In this study, ApoE-/- mice were fed a high-fat diet for 5 months. Urine samples from the experimental group and control group (C57BL/6 ...[more]

PMID: 36358920

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