Proteomics

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Shuangxinfang in Rats with Depression-behavior post Acute Myocardial Infarction from Proteomics

ABSTRACT: AMI models were established and PCF was administered in rats. Subjects were then assessed in an open field test recapitulating symptoms of depression. Afterward, pharmacoproteomic profiling of the hippocampus and peri-infarct border zone (BZ) was performed using a label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique, to identify contributing proteins and pathways responsible for myocardial ischemia and behavioral allostasis.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Zheyi Wang  

PROVIDER: PXD027832 | iProX | Tue Aug 10 00:00:00 BST 2021

REPOSITORIES: iProX

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Publications

Shuangxinfang Prevents S100A9-Induced Macrophage/Microglial Inflammation to Improve Cardiac Function and Depression-Like Behavior in Rats After Acute Myocardial Infarction.

Sun Yize Y   Wang Zheyi Z   Hou Jiqiu J   Shi Jinyu J   Tang Zhuoran Z   Wang Chao C   Zhao Haibin H  

Frontiers in pharmacology 20220624

<b>Background:</b> Depression is a common complication of cardiovascular disease, which deteriorates cardiac function. Shuangxinfang (psycho-cardiology formula, PCF) was reported to alleviate myocardial ischemia injury and improve depression-like behavior. Interestingly, our previous proteomics study predicted that the protein S100A9 appeared as an important target, and macrophage/microglial inflammation might be involved in the process of PCF improving depression induced by acute myocardial inf  ...[more]

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