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Elemonic acid inhibits colorectal cancer

ABSTRACT: Quantitative proteomic analysis reveals β-elemonic acid inhibiting colorectal cancer targeting tumor mitochondria and triggering ferroptosis

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Xia

PROVIDER: PXD027833 | iProX | Tue Aug 10 00:00:00 BST 2021

REPOSITORIES: iProX

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TMT-Based Quantitative Proteomics Analysis Reveals the Panoramic Pharmacological Molecular Mechanism of β-Elemonic Acid Inhibition of Colorectal Cancer.

Xia Yong Y Yang Jinfan J Li Chao C Hao Xiaopeng X Fan Huixia H Zhao Yuyang Y Tang Jinfu J Wan Xiufu X Lian Sen S Yang Jian J

Frontiers in pharmacology 20220215

Colorectal cancer (CRC) is one of the most common cancers worldwide but has limited available therapeutic methods; therefore, there is a need to develop highly efficient prevention and treatment strategies. Here, we investigated the anti-cancer activity of β-elemonic acid (EA) in CRC in vitro and in vivo. Our results showed that EA inhibited cell proliferation and migration in the CRC cell lines SW480 and HCT116. Moreover, EA significantly suppressed the growth of transplanted colo ...[more]

PMID: 35242040

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