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Water-soluble tomato extract Fruitflow alters the phosphoproteomic profile of collagen-stimulated platelets

ABSTRACT: The present study used proteomics to quantitatively analyze the effect of FF on the inhibition of collagen-stimulated platelets and validated the involvement of several signaling molecules.Fruitflow significantly inhibited human platelet aggregation and P-selectin expression that were induced by collagen. Proteomics analysis revealed that 60 proteins were upregulated in FF-treated collagen-stimulated platelets, and 10 proteins were downregulated in collagen-stimulated platelets alone. Additionally, 66 phosphorylated peptides were upregulated in FF-treated collagen-stimulated platelets, whereas 37 phosphorylated peptides were downregulated in collagen-stimulated platelets alone.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ruomei Qi

PROVIDER: PXD027834 | iProX | Tue Aug 10 00:00:00 BST 2021

REPOSITORIES: iProX

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Water-Soluble Tomato Extract Fruitflow Alters the Phosphoproteomic Profile of Collagen-Stimulated Platelets.

Zhang Shenghao S Chen Huilian H Li Chuanbao C Chen Beidong B Gong Huan H Zhao Yanyang Y Qi Ruomei R

Frontiers in pharmacology 20210927

Platelet hyperactivity is a risk factor for cardiovascular disease and thrombosis. Recent studies reported that the tomato extract Fruitflow inhibited platelet function, but the molecular mechanism is still unclear. The present study used proteomics to quantitatively analyze the effect of fruitflow on the inhibition of collagen-stimulated platelets and validated the involvement of several signaling molecules. Fruitflow significantly inhibited human platelet aggregation and P-selectin expression ...[more]

PMID: 34646142

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