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Preliminary investigation of iron acquisition mechanism in hypervirulent Klebsiella pneumoniae mediated by outer membrane vesicles

ABSTRACT: To investigate the role of outer membrane vesicles (OMVs) and related proteins in iron acquisition mechanism of hypervirulent Klebsiella pneumoniae (HVKP) and classic Klebsiella pneumoniae (cKP).

ORGANISM(S): Klebsiella Pneumoniae Subsp. Pneumoniae Ntuh-k2044 Klebsiella Pneumoniae

SUBMITTER: Wenen Liu

PROVIDER: PXD028057 | iProX | Sat Aug 21 00:00:00 BST 2021

REPOSITORIES: iProX

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Preliminary Investigation of Iron Acquisition in Hypervirulent <i>Klebsiella pneumoniae</i> Mediated by Outer Membrane Vesicles.

Lan You Y Zhou Mao M Li Xin X Liu Xuan X Li Jun J Liu Wenen W

Infection and drug resistance 20220202

<h4>Objective</h4>To investigate the role of outer membrane vesicles (OMVs) and related proteins in iron acquisition of hypervirulent <i>Klebsiella pneumoniae</i> (HVKP) and classic <i>Klebsiella pneumoniae</i> (cKP).<h4>Methods</h4>The OMVs of HVKP and cKP under iron-deficient and iron-sufficient media were extracted and purified by ultracentrifugation. Transmission electron microscopy (TEM) was used to identify OMVs. The quantitative proteomics were performed based on mass spectrometry.<h4>Res ...[more]

PMID: 35140477

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