Proteome-Centric Cross-Omics Characterization and Integrated Network Analyses of Triple-Negative Breast Cancer

ABSTRACT: We undertook the first systemic proteomic study of a 90-case cohort of triple-negative breast cancer (TNBC) with a panoramic proteome view in quantification, phosphorylation, and DNA-binding capacity. Four integrative subtypes (iP-1-4) were stratified based on the proteome quantification profile and phosphoproteome, each of which exhibited distinct molecular, pathway, and network characteristics. Integrated network analyses of 3 proteomic datasets, together with those of genome and transcriptome from the same cohort, revealed holistic views of altered cellular processes and their regulation by/of upstream/downstream molecules, pathways and functional communities in the background of an integrated molecular network.

ORGANISM(S): Homo Sapiens

SUBMITTER: Weimin Zhu  

PROVIDER: PXD028102 | iProX | Tue Aug 24 00:00:00 BST 2021

REPOSITORIES: iProX