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DIA proteomics analysis of wt and Prss37-null testis

ABSTRACT: The global proteome profiles of wild type (wt) and Prss37-null mice in testis were compared employing data independent acquisition (DIA) technology

ORGANISM(S): Mus Musculus

SUBMITTER: Zhugang Wang

PROVIDER: PXD028133 | iProX | Thu Aug 26 00:00:00 BST 2021

REPOSITORIES: iProX

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PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis.

Xiong Wenfeng W Ge Haoyang H Shen Chunling C Li Chaojie C Zhang Xiaohong X Tang Lingyun L Shen Yan Y Lu Shunyuan S Zhang Hongxin H Wang Zhugang Z

Reproductive sciences (Thousand Oaks, Calif.) 20220426 1

Our previous studies have reported that a putative trypsin-like serine protease, PRSS37, is exclusively expressed in testicular germ cells during late spermatogenesis and essential for sperm migration from the uterus into the oviduct and sperm-egg recognition via mediating the interaction between PDILT and ADAM3. In the present study, the global proteome profiles of wild-type (wt) and Prss37<sup>-/-</sup> mice in testis and sperm were compared employing data independent acquisition (DIA) technol ...[more]

PMID: 35471551

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