Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Jianping Guo
PROVIDER: PXD028167 | iProX | Fri Aug 27 00:00:00 BST 2021
REPOSITORIES: iProX
Jiang Qiwei Q Zhang Xiaomei X Dai Xiaoming X Han Shiyao S Wu Xueji X Wang Lei L Wei Wenyi W Zhang Ning N Xie Wei W Guo Jianping J
Nature communications 20220322 1
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), directly phosphorylates PDK1 at its pleckstrin homology (PH) domai ...[more]