Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

ABSTRACT: Mouse of SiO2 group were instilled with silica suspension, and mouse of control group were instilled with NS. The mouse mouse were raised for 56 d, and then the ECM was harvest. We found out the main protein deposited in fabrotic lung ECM. By spatial transcriptomics, we analyzed the distribution pattern of transcripts in space. Using sc-RNA sequencing, we investigated the cell resource of IgA.

ORGANISM(S): Mus Musculus

SUBMITTER: Jie Chao  

PROVIDER: PXD028194 | iProX | Tue Aug 31 00:00:00 GMT+01:00 2021

REPOSITORIES: iProX