Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Haojie Lu
PROVIDER: PXD028212 | iProX | Sat Sep 04 00:00:00 BST 2021
REPOSITORIES: iProX
Cao Xinyi X Meng Peiyi P Shao Yuyin Y Yan Guoquan G Yao Jun J Zhou Xinwen X Liu Chao C Zhang Lei L Shu Hong H Lu Haojie H
Frontiers in molecular biosciences 20220427
Glycosylation inhibition has great potential in cancer treatment. However, the corresponding cellular response, protein expression and glycosylation changes remain unclear. As a cell-permeable small-molecule inhibitor with reduced cellular toxicity, N-linked glycosylation inhibitor-1 (NGI-1) has become a great approach to regulate glycosylation in mammalian cells. Here for the first time, we applied a nascent proteomic method to investigate the effect of NGI-1 in hepatocellular carcinoma (HCC) c ...[more]