Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Lemin Zheng
PROVIDER: PXD028230 | iProX | Wed Sep 08 00:00:00 BST 2021
REPOSITORIES: iProX
Zhao Mingming M Wei Haoran H Li Chenze C Zhan Rui R Liu Changjie C Gao Jianing J Yi Yaodong Y Cui Xiao X Shan Wenxin W Ji Liang L Pan Bing B Cheng Si S Song Moshi M Sun Haipeng H Jiang Huidi H Cai Jun J Garcia-Barrio Minerva T MT Chen Y Eugene YE Meng Xiangbao X Dong Erdan E Wang Dao Wen DW Zheng Lemin L
Nature communications 20220401 1
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression still remain unclear. N,N,N-trimethyl-5-aminovaleric acid (TMAVA), derived from trimethyllysine through the gut microbiota, was elevated with gradually increased risk of cardiac mortality and transpla ...[more]