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Proteomic change in cerebrospinal fluid of neonatal sepsis

ABSTRACT: Neonatal infection and sepsis are common for preterm infants due to their immature immune system. Acute changes of proteins in the cerebrospinal fluid (CSF), potentially affect the immature brain of preterm neonates. In this study, collected human CSF samples were processed according to the enhanced ﬁlter-aided sample preparation (eFASP) protocol and run on a Dionex RSLC UPLC System coupled to an Orbitrap Fusion Lumos Mass Spectrometer. Protein annotation and quantiﬁcation were carried out using MaxQuant (version 1.5.2.8) against the Uniprot database (homo sapiens, UP0000085640).

ORGANISM(S): Homo Sapiens

SUBMITTER: Pingping Jiang

PROVIDER: PXD028442 | iProX | Thu Sep 09 00:00:00 BST 2021

REPOSITORIES: iProX

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Proteins Involved in Synaptic Plasticity Are Downregulated in the Cerebrospinal Fluid of Infants With Clinical Sepsis Complicated by Neuroinflammation.

Jiang Ping-Ping PP Peng Shan-Shan SS Pankratova Stanislava S Luo Ping P Zhou Ping P Chen You Y

Frontiers in cellular neuroscience 20220511

Newborn infants are prone to sepsis and related inflammation of different organs. Neuroinflammation has been associated with long-term adverse neuronal (neuropsychiatric/neurodegenerative) outcomes, including attention deficit hyperactivity disorder (ADHD) or even Alzheimer's disease. Despite a vast number of findings on sepsis-induced inflammatory responses in the central nervous system (CNS), how neuroinflammation affects brain development remains largely elusive. In this study, neonates with ...[more]

PMID: 35634471

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