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DIA proteomics analysis of RNF223 knockdown and control pancreatic cancer cell lines

ABSTRACT: The proteome profiles of RNF223 knockdown and control pancreatic cancer cell lines were compared employing data independent acquisition(DIA) technology

ORGANISM(S): Homo Sapiens

SUBMITTER: Chenjie Zhou

PROVIDER: PXD028446 | iProX | Fri Sep 10 00:00:00 BST 2021

REPOSITORIES: iProX

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Comprehensive Analysis of E3 Ubiquitin Ligases Reveals Ring Finger Protein 223 as a Novel Oncogene Activated by KLF4 in Pancreatic Cancer.

Feng Lei L Wang Jieqing J Zhang Jianmin J Diao Jingfang J He Longguang L Fu Chaoyi C Liao Hui H Xu Xiaoping X Gao Yi Y Zhou Chenjie C

Frontiers in cell and developmental biology 20211014

Pancreatic cancer is one of the major malignancies and causes of mortality worldwide. E3 ubiquitin-protein ligases transfer activated ubiquitin from ubiquitin-conjugating enzymes to protein substrates and confer substrate specificity in cancer. In this study, we first downloaded data from The Cancer Genome Atlas pancreatic adenocarcinoma dataset, acquired all 27 differentially expressed genes (DEGs), and identified genomic alterations. Then, the prognostic significance of DEGs was analyzed, and ...[more]

PMID: 34722520

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