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Cardiac proteomics in diabetic cardiomyopathy mice treated with GLP-1 receptor agonist

ABSTRACT: the changes of cardiac proteomics in diabetic cardiomyopathy mice treated with GLP-1 receptor agonist

ORGANISM(S): Mus Musculus

SUBMITTER: Keqin Zhang

PROVIDER: PXD028452 | iProX | Fri Sep 10 00:00:00 BST 2021

REPOSITORIES: iProX

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Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP.

Fang Ping P Ye Zhengqin Z Li Ran R She Dunmin D Zong Guannan G Zhang Liya L Xue Ying Y Zhang Keqin K

Drug design, development and therapy 20230312

<h4>Purpose</h4>Our aims were to investigate the pathogenesis of diabetic cardiomyopathy (DCM) and to explore the protective effect of glucagon-like peptide-1 receptor agonist (GLP-1RA) on DCM.<h4>Methods</h4>After 12 weeks of treatment with exenatide-loaded microspheres, a long-acting GLP-1RA, in DCM mice, cardiac structure and function were evaluated by plasma B-type natriuretic peptide (BNP), echocardiography, H&E, oil red and Sirius staining. The expression of glucagon-like peptide-1 recepto ...[more]

PMID: 36936522

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