Quantitative proteomic analysis of the injured sciatic nerve of wild-type and WldS mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yanshan Fang
PROVIDER: PXD028726 | iProX | Thu Sep 23 00:00:00 BST 2021
REPOSITORIES: iProX
Publications
Quantitative Proteomic Analysis of Mouse Sciatic Nerve Reveals Post-injury Upregulation of ADP-Dependent Glucokinase Promoting Macrophage Phagocytosis.
Zhang Kai K Wang Qingyao Q Liang Yiyao Y Yan Yu Y Wang Haiqiong H Cao Xu X Shan Bing B Zhang Yaoyang Y Li Ang A Fang Yanshan Y
Frontiers in molecular neuroscience 20211112
Nerve injury induces profound and complex changes at molecular and cellular levels, leading to axonal self-destruction as well as immune and inflammatory responses that may further promote neurodegeneration. To better understand how neural injury changes the proteome within the injured nerve, we set up a mouse model of sciatic nerve injury (SNI) and conducted an unbiased, quantitative proteomic study followed by biochemical assays to confirm some of the changed proteins. Among them, the protein ...[more]
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