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Identification of OTUD3 interactors in esophageal cancer cell line

ABSTRACT: Immunoprecipitation of OTUD3 interacting proteins was subjected to SDS-PAGE, silver-stained, and identified by mass spectrometry (MS).

ORGANISM(S): Homo Sapiens

SUBMITTER: Libing Song

PROVIDER: PXD028751 | iProX | Sun Sep 26 00:00:00 BST 2021

REPOSITORIES: iProX

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Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.

Wang Meng M Li Yue Y Xiao Yunyun Y Yang Muwen M Chen Jinxin J Jian Yunting Y Chen Xin X Shi Dongni D Chen Xiangfu X Ouyang Ying Y Kong Lingzhi L Huang Xinjian X Bai Jiewen J Lin Chuyong C Song Libing L

Nature communications 20211201 1

Nicotine addiction and the occurrence of lymph node spread are two major significant factors associated with esophageal cancer's poor prognosis; however, nicotine's role in inducing lymphatic metastasis of esophageal cancer remains unclear. Here we show that OTU domain-containing protein 3 (OTUD3) is downregulated by nicotine and correlates with poor prognosis in heavy-smoking esophageal cancer patients. OTUD3 directly interacts with ZFP36 ring finger protein (ZFP36) and stabilizes it by inhibit ...[more]

PMID: 34853315

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