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Proteogenomic Discovery of sORF-encoded Peptides in Yersinia pestis Reveals Regulatory Phenotype on Bacterial Virulence

ABSTRACT: An integrated pipeline for discovery of SEPs were established including modules of prediction, discovery and curation.

ORGANISM(S): Yersinia Pestis Biovar Microtus Str. 91001

SUBMITTER: Chenxi Jia

PROVIDER: PXD028891 | iProX | Sun Oct 03 00:00:00 BST 2021

REPOSITORIES: iProX

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Proteogenomic discovery of sORF-encoded peptides associated with bacterial virulence in Yersinia pestis.

Cao Shiyang S Liu Xinyue X Huang Yin Y Yan Yanfeng Y Zhou Congli C Shao Chen C Yang Ruifu R Zhu Weimin W Du Zongmin Z Jia Chenxi C

Communications biology 20211102 1

Plague caused by Yersinia pestis is one of the deadliest diseases. However, many molecular mechanisms of bacterial virulence remain unclear. This study engaged in the discovery of small open reading frame (sORF)-encoded peptides (SEPs) in Y. pestis. An integrated proteogenomic pipeline was established, and an atlas containing 76 SEPs was described. Bioinformatic analysis indicated that 20% of these SEPs were secreted or localized to the transmembrane and that 33% contained functional domains. Tw ...[more]

PMID: 34728737

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