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A C-terminal tail deletion of histidine kinase WalK/VicK disrupted transcriptional regulation in Streptococcus mutans

ABSTRACT: An essential two-component system WalRK is required for biofilm formation of streptococcus mutans mainly through transcriptional regulations.

ORGANISM(S): Streptococcus Mutans Ua159

SUBMITTER: Aidong Han

PROVIDER: PXD028893 | iProX | Thu Sep 30 00:00:00 BST 2021

REPOSITORIES: iProX

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The W-Acidic Motif of Histidine Kinase WalK Is Required for Signaling and Transcriptional Regulation in <i>Streptococcus mutans</i>.

Kong Lingyuan L Su Mingyang M Sang Jiayan J Huang Shanshan S Wang Min M Cai Yongfei Y Xie Mingquan M Wu Jun J Wang Shida S Foster Simon J SJ Zhang Jiaqin J Han Aidong A

Frontiers in microbiology 20220426

In <i>Streptococcus mutans</i>, we find that the histidine kinase WalK possesses the longest C-terminal tail (CTT) among all 14 TCSs, and this tail plays a key role in the interaction of WalK with its response regulator WalR. We demonstrate that the intrinsically disordered CTT is characterized by a conserved tryptophan residue surrounded by acidic amino acids. Mutation in the tryptophan not only disrupts the stable interaction, but also impairs the efficient phosphotransferase and phosphatase a ...[more]

PMID: 35558126

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