Multi-omics profiling identifies pathways associated with CD8+ T cell activation in severe aplastic anemia
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Zhexiong Lian
PROVIDER: PXD029024 | iProX | Sat Oct 09 00:00:00 BST 2021
REPOSITORIES: iProX
Publications
Multi-Omics Profiling Identifies Pathways Associated With CD8<sup>+</sup> T-Cell Activation in Severe Aplastic Anemia.
You Xing X Yang Qiong Q Yan Kai K Wang Song-Rong SR Huang Rong-Rong RR Wang Shun-Qing SQ Gao Cai-Yue CY Li Liang L Lian Zhe-Xiong ZX
Frontiers in genetics 20220104
Severe aplastic anemia (SAA) is an autoimmune disease characterized by immune-mediated destruction of hematopoietic stem and progenitor cells. Autoreactive CD8<sup>+</sup> T cells have been reported as the effector cells; however, the mechanisms regulating their cell activation in SAA remain largely unknown. Here, we performed proteomics and metabolomics analyses of plasma and bone marrow supernatant, together with transcriptional analysis of CD8<sup>+</sup> T cells from SAA patients and healthy ...[more]
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