Proteomics

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Complement C4-A and Plasminogen Q1 Q2 as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma


ABSTRACT: Serum samples were collected from 29 PTC patients and 29 nodular goiter (NG) patients. Five PTC serum samples and five NG serum samples were selected for proteome profiles by proteomics. Eight proteins in PTC and NG serum samples were selected for confirmation by enzyme-linked immunosorbent assay analysis. Receiver perating characteristic curves was used to evaluate the diagnostic value of potential biomarkers.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhihui Li  

PROVIDER: PXD029304 | iProX | Sat Oct 23 00:00:00 BST 2021

REPOSITORIES: iProX

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Publications

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma.

Wang Yichao Y   Zhou Shengliang S   Wang Dun D   Wei Tao T   Zhu Jingqiang J   Li Zhihui Z  

Frontiers in endocrinology 20211105


<h4>Background</h4>Early diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC.<h4>Methods</h4>Serum samples were collected from 29 PTC patients and 29 nodular goiter (NG) patients. Five PTC serum samples and five NG serum samples were selected for proteome profiles by  ...[more]

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