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ITRAQ of HEK293T-cell protein 48 hours after transfection of phagocytophilic anaplastic effector protein Ats-1

ABSTRACT: ITRAQ of HEK293T-cell protein 48 hours after transfection of phagocytophilic anaplastic effector protein Ats-1

ORGANISM(S): Homo Sapiens

SUBMITTER: Changfu Chen

PROVIDER: PXD029412 | iProX | Thu Oct 28 00:00:00 BST 2021

REPOSITORIES: iProX

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Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria.

Li Ruirui R Ma Zhongchen Z Zheng Wei W Wang Zhen Z Yi Jihai J Xiao Yangyang Y Wang Yong Y Chen Chuangfu C

BMC microbiology 20221111 1

<h4>Background</h4>Anaplasma translocated substrate 1 (Ats-1) is an effector of type 4 secretory systems (T4SS) and the main virulence factor of Anaplasma phagocytophilum. Ats-1 is involved in the regulation of host cell biological processes, but the specific molecular mechanism of its action is unclear.<h4>Results</h4>In this study, we identified Ats-1 as involved in mitochondrial respiratory regulation of HEK293T cells by multi-omics analysis. After intracellular expression of Ats-1, adenosine ...[more]

PMID: 36357826

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