Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Lunzhi Dai
PROVIDER: PXD029445 | iProX | Fri Oct 29 00:00:00 BST 2021
REPOSITORIES: iProX
Tan Yuping Y Zhou Xia X Gong Yanqiu Y Gou Kun K Luo Youfu Y Jia Da D Dai Lunzhi L Zhao Yinglan Y Sun Qingxiang Q
Cellular and molecular life sciences : CMLS 20211231 1
The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated promising tumor-suppressing activities. However, the enzyme properties of PHGDH are not well understood and the discovery of PHGDH inhibitors is still in its infancy. Here, oridonin was identified from a natural product library as a new PHGDH inhibitor. The crystal structure of PHGDH in complex with oridonin revealed a new alloster ...[more]