Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target

ABSTRACT: Here, we presented a streamlined workflow to measure abundant AMG510 modified peptides including that of KRAS/G12C by direct profiling, and a pan-AMG510 antibody peptide IP workflow to profile less abundant AMG510 off-targets.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jun Qin  

PROVIDER: PXD029449 | iProX | Wed Jan 11 00:00:00 GMT 2023

REPOSITORIES: iProX