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Lysine Succinylation in Human Lungs

ABSTRACT: In this study, we performed LC-MS/MS for global profiling of succinylation in 6 human lungs under normal physiological conditions. Our work will help for further study the function of succinylation modification in various physiology and pathology, as well as the energy metabolism and the regulation of tumor and immunity.

ORGANISM(S): Homo Sapiens

SUBMITTER: Juntao Yang

PROVIDER: PXD029533 | iProX | Tue Nov 02 00:00:00 GMT 2021

REPOSITORIES: iProX

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Global profiling of lysine succinylation in human lungs.

Yang Ye-Hong YH Wu Song-Feng SF Zhu Yun-Ping YP Yang Jun-Tao JT Liu Jiang-Feng JF

Proteomics 20220609 17

The lysine succinylation (Ksucc) is involved in many core energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying diseases related to mitochondrial disorders. In this paper, we used liquid chromatography with tandem mass spectrometry (LC-MS/MS) to perform the first global profiling of succinylation in human lungs under normal physiological conditions. Using an MS-based platform, we identified 1485 Ksucc sites in 568 prot ...[more]

PMID: 35644922

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