Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Serum proteomic analysis identifies SAA1, FGA，SAP and CETP as new biomarkers for Eosinophilic granulomatosis with polyangiitis

ABSTRACT: Our findings suggest that DIA combined with PRM mass spectrometric method was effective in identifying and validating the candidate biomarkers for several diseases including EGPA diagnosis. We have discovered and validated three new potentially serum biomarkers FGA, SAP and CETP for discriminating EGPA from severe asthma groups. These potential biomarkers might be of great importance to diagnosis EGPA.

ORGANISM(S): Homo Sapiens

SUBMITTER: Fei Long

PROVIDER: PXD029759 | iProX | Tue Feb 15 00:00:00 GMT 2022

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Publications

Serum Proteomic Analysis Identifies SAA1, FGA, SAP, and CETP as New Biomarkers for Eosinophilic Granulomatosis With Polyangiitis.

Xiao Jing J Lu Shaohua S Wang Xufei X Liang Mengdi M Dong Cong C Zhang Xiaoxian X Qiu Minzhi M Ou Changxing C Zeng Xiaoyin X Lan Yanting Y Hu Longbo L Tan Long L Peng Tao T Zhang Qingling Q Long Fei F

Frontiers in immunology 20220610

<h4>Background</h4>Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by asthma-like attacks in its early stage, which is easily misdiagnosed as severe asthma. Therefore, new biomarkers for the early diagnosis of EGPA are needed, especially for differentiating the diagnosis of asthma.<h4>Objectives</h4>To identify serum biomarkers that can be used for early diagnosis of EGPA and to distinguish EGPA from severe asthma.<h4>Method</h4>Data-independent acquisition (DIA) analysis w ...[more]

PMID: 35757752

Similar Datasets

A new strategy to identify the long-distance mobile peptides from xylem sap.

Project description:Total RNAs were extracted from internodes and roots of 18 day-after-germination soybean plants, and the expression levels of the genes that encode xylem sap associated peptides or proteins were analyzed.

2015-10-23 | E-MTAB-5052 | biostudies-arrayexpress

Transcriptome analysis of germinal center B cells of WT and SAP-deficient mice

Project description:Analysis of germinal center B cells derived from WT and SAP-deficient mice revealed that SAP-deficient mice have reduced Myc signature

2019-12-28 | GSE142640 | GEO

The small RNA component of Arabidopsis phloem sap and its response to iron deficiency.

Project description:We performed small RNA-seq (sRNA-seq) study of Arabidopsis phloem sap under iron-sufficient (+Fe; control) and iron deficient (-Fe) conditions to investigate and identify sRNAs whose expression is regulated by iron deficiency in the phloem sap.

2023-08-08 | GSE223278 | GEO

Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation [CutandRun]

Project description:SAF-A is conserved throughout vertebrates and has emerged as an important factor regulating a multitude of nuclear functions, including lncRNA localization, gene expression, and splicing. SAF-A has several functional domains, including an N-terminal SAP domain that binds directly to DNA. Phosphorylation of SAP domain serines S14 and S26 are important for SAF-A localization and function during mitosis, however whether these serines are involved in interphase functions of SAF-A is not known. In this study we tested for the role of the SAP domain, and SAP domain serines S14 and S26 in X chromosome inactivation, protein dynamics, gene expression, splicing, and cell proliferation. Here we show that the SAP domain serines S14 and S26 are required to maintain XIST RNA localization and polycomb-dependent histone modifications on the inactive X chromosome in female cells. In addition, we present evidence that an Xi localization signal resides in the SAP domain. We found that that the SAP domain is not required to maintain gene expression and plays only a minor role in mRNA splicing. In contrast, the SAF-A SAP domain, in particular serines S14 and S26, are required for normal protein dynamics, and to maintain normal cell proliferation. We propose a model whereby dynamic phosphorylation of SAF-A serines S14 and S26 mediates rapid turnover of SAF-A interactions with DNA during interphase.

2025-05-14 | GSE277217 | GEO

Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation [RNA-seq]

2025-05-14 | GSE277221 | GEO

Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation [DNA-seq]

2025-05-14 | GSE277219 | GEO

Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation [ATAC-seq]

2025-05-14 | GSE277216 | GEO

SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

Project description:During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developmental programming remain unclear. Recently, we demonstrated that the SLAM-SAP signaling pathway regulates the development and function of multiple innate-like γδ T cell subsets. Here, we used a single-cell proteogenomics approach to identify SAP-dependent developmental checkpoints and to define the SAP-dependent γδ TCR repertoire. SAP deficiency resulted in both a significant loss of an immatureGzma+Blk+Etv5+Tox2+γδT17 precursor population, and a significant increase inCd4+Cd8+Rorc+Ptcra+Rag1+thymic γδ T cells. SAP-dependent diversion of embryonic day 17 thymic γδ T cell clonotypes into the αβ T cell developmental pathway was associated with a decreased frequency of mature clonotypes in neonatal thymus, and an altered γδ TCR repertoire in the periphery. Finally, we identify TRGV4/TRAV13-4(DV7)-expressing T cells as a novel, SAP-dependent Vγ4 γδT1 subset. Together, the data suggest that SAP-dependent γδ/αβ T cell lineage commitment regulates γδ T cell developmental programming and shapes the γδ TCR repertoire.

2024-07-08 | GSE262064 | GEO

Transcriptomics of Xanthomonas campestris pv campestris in cabbage xylem sap

Project description:Xylem sap of young cabbage plantlets was recovered from root pressure exudation and used as a growth medium for the vascular pathogen Xanthomonas campestris pv campestris, the causative agent of the black rot of Brassicaceae.

2014-01-04 | E-MTAB-2290 | biostudies-arrayexpress

Xylem sap shotgun proteomics from Mn-excess tomato plants

Project description:The aim of this work was to study the effects of Mn excess on the protein profile of the xylem sap of tomato (Solanum lycopersicum), with the aim of elucidating plant response mechanisms to these nutritional stresses. Tomato was chosen as a model plant because the tomato genome has been published and this plant species has adequate root pressure and turgid stems that permit xylem sap sampling in sufficient amounts by de-topping. The high- throughput shotgun analysis has permitted to identify and quantitate a large number of low abundance proteins in the tomato xylem sap.

2020-12-10 | PXD021973 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data