Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Bingqiao Zhao
PROVIDER: PXD029910 | iProX | Thu Nov 25 00:00:00 GMT 2021
REPOSITORIES: iProX
Yu Huilin H Luo Haiyu H Chang Luping L Wang Shisheng S Geng Xue X Kang Lijing L Zhong Yi Y Cao Yongliang Y Wang Ranran R Yang Xing X Zhu Yuanbo Y Shi Mei-Juan MJ Hu Yue Y Liu Zhongwang Z Yin Xuhui X Ran Yunwei Y Yang Hao H Fan Wenying W Zhao Bing-Qiao BQ
Proceedings of the National Academy of Sciences of the United States of America 20220201 6
Blood-brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly a deleterious role in the pathophysiology of ischemic stroke. Neddylation is a ubiquitylation-like pathway that is critical in various cellular functions by conjugating neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to target proteins. However, the roles of neddylation pathway in ischemic stroke remain elusive. Here, we report that NEDD8 conjugation increased during ac ...[more]