Proteomics

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The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice


ABSTRACT: To investigate protein expression differences in the ischemic brain between mice treated with vehicle and MLN4924, high-throughput proteomics Liquid Chromatography-Mass Spectrometry (LC-MS)-based analysis was performed.

ORGANISM(S): Mus Musculus

SUBMITTER: Bingqiao Zhao  

PROVIDER: PXD029910 | iProX | Thu Nov 25 00:00:00 GMT 2021

REPOSITORIES: iProX

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The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice.

Yu Huilin H   Luo Haiyu H   Chang Luping L   Wang Shisheng S   Geng Xue X   Kang Lijing L   Zhong Yi Y   Cao Yongliang Y   Wang Ranran R   Yang Xing X   Zhu Yuanbo Y   Shi Mei-Juan MJ   Hu Yue Y   Liu Zhongwang Z   Yin Xuhui X   Ran Yunwei Y   Yang Hao H   Fan Wenying W   Zhao Bing-Qiao BQ  

Proceedings of the National Academy of Sciences of the United States of America 20220201 6


Blood-brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly a deleterious role in the pathophysiology of ischemic stroke. Neddylation is a ubiquitylation-like pathway that is critical in various cellular functions by conjugating neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to target proteins. However, the roles of neddylation pathway in ischemic stroke remain elusive. Here, we report that NEDD8 conjugation increased during ac  ...[more]

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