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HOTAIR knockdown glioma cell proteomics

ABSTRACT: This study demonstrated the effects of lncRNA HOTAIR knockdown on the glioma proteomics. An abnormally high expression of the lncRNA HOTAIR has been previously demonstrated in glioma cells. HOTAIR regulates genes by anchoring epigenetic modification proteins and causes abnormalities in multiple signaling pathways. We knocked down HOTAIR in glioma cells by siRNA with SILAC labeling, and then total protein was extracted for proteome mass spectrometry.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chunsheng Kang

PROVIDER: PXD029919 | iProX | Fri Dec 31 00:00:00 GMT 2021

REPOSITORIES: iProX

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HOTAIR Up-Regulation Activates NF-κB to Induce Immunoescape in Gliomas.

Wang Yunfei Y Yi Kaikai K Liu Xing X Tan Yanli Y Jin Weili W Li Yansheng Y Zhou Junhu J Wang Hongjun H Kang Chunsheng C

Frontiers in immunology 20211123

<h4>Background</h4>Checkpoint blockade therapies targeting programmed death ligand 1 (PD-L1) and its receptor programmed cell death 1 promote T cell-mediated immune surveillance against tumors and have been associated with significant clinical benefit in cancer patients. The long-stranded non-coding RNA HOTAIR is highly expressed and associated with metastasis in a variety of cancer types and promotes tumor metastasis at least in part through association with the PRC2 complex that induces redire ...[more]

PMID: 34887871

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