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Requirement of Rbx1 Cullin-RING ligase E3 and Ube2m neddylation E2 in the maintenance of the fitness of Treg cells

ABSTRACT: the Ube2m-Rbx1 axis is required for the maintenance of homeostasis and functions of Treg cells; and Rbx1 has Ube2m-independent roles in the fitness of Treg cells, suggesting a layer of complexity in neddylation activation of CRLs.

ORGANISM(S): Mus Musculus

SUBMITTER: Yi Sun

PROVIDER: PXD030144 | iProX | Fri Dec 03 00:00:00 GMT 2021

REPOSITORIES: iProX

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The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.

Wu Di D Li Haomin H Liu Mingwei M Qin Jun J Sun Yi Y

Nature communications 20220531 1

Neddylation-mediated activation of Cullin-RING E3 Ligases (CRLs) are necessary for the degradation of specific immune regulatory proteins. However, little is known about how these processes govern the function of regulatory T (Treg) cells. Here we show that mice with Treg cell-specific deletion of Rbx1, a dual E3 for both neddylation and ubiquitylation by CRLs, develop an early-onset fatal inflammatory disorder, characterized by disrupted Treg cell homeostasis and suppressive functions. Specific ...[more]

PMID: 35641500

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