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Proteomics analysis of human amniotic epithelial cell-derived extracellular vesicles

ABSTRACT: Proteomics analysis of human amniotic epithelial cell-derived extracellular vesicles.

ORGANISM(S): Homo Sapiens

SUBMITTER: Qingjian Ou

PROVIDER: PXD030221 | iProX | Tue Dec 07 00:00:00 GMT 2021

REPOSITORIES: iProX

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Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair.

Hu Shuqin S Wang Zhe Z Jin Caixia C Chen Qizhen Q Fang Yuchen Y Jin Jiahui J Chen Jie J Lu Lixia L Tian Haibin H Xu Jingying J Gao Furong F Wang Juan J Zhang Jieping J Cui Hong-Ping HP Xu Guo-Tong GT Ou Qingjian Q

Journal of tissue engineering 20220101

To study the biological functions and applications of human amniotic epithelial cell-derived extracellular vesicles (hAEC-EVs), the cargos of hAEC-EVs were analyzed using miRNA sequencing and proteomics analysis. The hAECs and hAEC-EVs in this study had specific characteristics. Multi-omics analyses showed that extracellular matrix (ECM) reorganization, inhibition of excessive myofibroblasts, and promotion of target cell adhesion to the ECM were their primary functions. We evaluated the applicat ...[more]

PMID: 36093432

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