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A Proteogenomic Analysis of Clear Cell Renal Cell Carcinoma in a Chinese Population

ABSTRACT: We performed proteomic analysis of 232 ccRCC patients samples.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Ding

PROVIDER: PXD030344 | iProX | Sat Apr 16 00:00:00 BST 2022

REPOSITORIES: iProX

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A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population.

Qu Yuanyuan Y Feng Jinwen J Wu Xiaohui X Bai Lin L Xu Wenhao W Zhu Lingli L Liu Yang Y Xu Fujiang F Zhang Xuan X Yang Guojian G Lv Jiacheng J Chen Xiuping X Shi Guo-Hai GH Wang Hong-Kai HK Cao Da-Long DL Xiang Hang H Li Lingling L Tan Subei S Gan Hua-Lei HL Sun Meng-Hong MH Qiu Jiange J Zhang Hailiang H Zhao Jian-Yuan JY Ye Dingwei D Ding Chen C

Nature communications 20220419 1

Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tumor adjacent tissues, we find that ccRCC shows extensive metabolic dysregulation and an enhanced immune response. Molecular subtyping classifies ccRCC tumors into three subtypes (GP1-3), among which the most aggressive GP1 exhibits the strongest immune ph ...[more]

PMID: 35440542

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