Proteomics

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SILAC experiments profiling of the proteome of WT and CobB KO E.coli

ABSTRACT: SILAC experiments profiling of the proteome of WT and CobB KO E.coli

ORGANISM(S): Escherichia Coli

SUBMITTER: Kai Zhang  

PROVIDER: PXD030345 | iProX | Sat Dec 11 00:00:00 GMT 2021

REPOSITORIES: iProX

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Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in human cells. However, the characterization, regulatory mechanism and functional consequence of Kla in prokaryotes remain unclear. Here, we report that YiaC functions as a lysine lactylase and that CobB serves as a lysine delactylase in the regulation of metabolism. We demonstrate that YiaC catalyzes the addition of Kla, while CobB erases this PTM both in vitro and intracellularly. Moreover, we show  ...[more]

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