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HRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

ABSTRACT: As a ubiquitin ligase, HRD1 may regulate FGF21 expression through targeting protein degradation. We then aimed to identify proteins whose expressions are altered at post-transcriptional levels in HRD1 LKO mouse liver

ORGANISM(S): Mus Musculus

SUBMITTER: Jian Wang

PROVIDER: PXD030410 | iProX | Tue Dec 14 00:00:00 GMT 2021

REPOSITORIES: iProX

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HRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination.

Wei Juncheng J Chen Lu L Li Fei F Yuan Yanzhi Y Wang Yajun Y Xia Wanjun W Zhang Yuehui Y Xu Yuanming Y Yang Zhao Z Gao Beixue B Jin Chaozhi C Melo-Cardenas Johanna J Green Richard M RM Pan Hui H Wang Jian J He Fuchu F Zhang Kezhong K Fang Deyu D

The EMBO journal 20181102 22

The endoplasmic reticulum-associated protein degradation (ERAD) is responsible for recognizing and retro-translocating protein substrates, misfolded or not, from the ER for cytosolic proteasomal degradation. HMG-CoA Reductase (HMGCR) Degradation protein-HRD1-was initially identified as an E3 ligase critical for ERAD. However, its physiological functions remain largely undefined. Herein, we discovered that hepatic HRD1 expression is induced in the postprandial condition upon mouse refeeding. Mice ...[more]

PMID: 30389664

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