Proteomics

Dataset Information

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Human Plasma Proteome by Isobaric Tags for Relative and Absolute Quantitation Based Quantitative Proteomics Technique


ABSTRACT: This project was to identify relevant diagnostic biomarkers for vascular aging by performing a targeted proteomic comparison of plasma proteins between aortic stiffness (high PWV) and non-aortic stiffness (normal PWV) populations using isobaric tags for relative and absolute quantitation based quantitative proteomics technique

ORGANISM(S): Homo Sapiens

SUBMITTER: Cuntai Zhang  

PROVIDER: PXD030531 | iProX | Sun Dec 19 00:00:00 GMT 2021

REPOSITORIES: iProX

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Publications

Association Between Plasma Fibulin-1 and Brachial-Ankle Pulse Wave Velocity in Arterial Stiffness.

Luo Mandi M   Yan Dan D   Liang Xiaolu X   Huang Yi Y   Luo Pengcheng P   Yang Zhen Z   Zhang Yucong Y   Xu Ting T   Gao Shangbang S   Zhang Le L   Zhou Yiwu Y   Shi Qing Q   Zhang Cuntai C   Ruan Lei L  

Frontiers in cardiovascular medicine 20220707


Arterial stiffness forms the basis of cardiovascular diseases (CVD) and is also an independent predictor of CVD risk. Early detection and intervention of arterial stiffness are important for improving the global burden of CVD. Pulse wave velocity (PWV) is the gold standard for assessing arterial stiffness and the molecular mechanism of arterial stiffness remains to be studied. Extracellular matrix (ECM) remodeling is one of the major mechanisms of arterial stiffness. Partial quantitative changes  ...[more]

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