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AI-based multi-omic integration uncovers Atg1 interactome and substratome in yeast autophagy

ABSTRACT: As a core Autophagy-related (Atg) protein during yeast autophagy, Atg1 interacts with numerous other proteins, and its kinase activity facilitates to phosphorylate various substrates. How Atg1-interacting partners and substrates synergistically orchestrate autophagy remains to be further dissected. In this study, we conducted a transcriptomic, proteomic and phosphoproteomic profiling of Atg1-dependent molecular landscapes during nitrogen starvation-triggered autophagy.

ORGANISM(S): Saccharomyces Cerevisiae

SUBMITTER: Yu Xue

PROVIDER: PXD030628 | iProX | Thu Dec 23 00:00:00 GMT 2021

REPOSITORIES: iProX

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