Ontology highlight
ABSTRACT:
ORGANISM(S): Mus <genus>
SUBMITTER: Siqi Liu
PROVIDER: PXD030647 | iProX | Sat Dec 25 00:00:00 GMT 2021
REPOSITORIES: iProX
Yan Keqiang K Mei Zhanlong Z Zhao Jingjing J Prodhan Md Aminul Islam MAI Obal Detlef D Katragadda Kartik K Doelling Benjamin B Hoetker David D Posa Dheeraj Kumar DK He Liqing L Yin Xinmin X Shah Jasmit J Pan Jianmin J Rai Shesh S Lorkiewicz Pawel Konrad PK Zhang Xiang X Liu Siqi S Bhatnagar Aruni A Baba Shahid P SP
Journal of the American Heart Association 20220622 13
Background Histidyl dipeptides such as carnosine are present in a micromolar to millimolar range in mammalian hearts. These dipeptides facilitate glycolysis by proton buffering. They form conjugates with reactive aldehydes, such as acrolein, and attenuate myocardial ischemia-reperfusion injury. Although these dipeptides exhibit multifunctional properties, a composite understanding of their role in the myocardium is lacking. Methods and Results To identify histidyl dipeptide-mediated responses in ...[more]