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Explore the proteomics characteristics of urine and serum from COVID-19 patients

ABSTRACT: we obtained the proteome profiling of serum and urine specimen collected from 50 COVID-19 patients and 40 healthy subjects. We then used TMT-labeled proteomics and quantified 1,494 and 3,854 proteins in serum and urine, respectively. We then explored the pathogenic characteristics in body fluids after SARS-CoV-2 infection.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan Guo

PROVIDER: PXD030662 | iProX | Thu Dec 30 00:00:00 GMT 2021

REPOSITORIES: iProX

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Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19.

Bi Xiaojie X Liu Wei W Ding Xuan X Liang Shuang S Zheng Yufen Y Zhu Xiaoli X Quan Sheng S Yi Xiao X Xiang Nan N Du Juping J Lyu Haiyan H Yu Die D Zhang Chao C Xu Luang L Ge Weigang W Zhan Xinke X He Jiale J Xiong Zi Z Zhang Shun S Li Yanchang Y Xu Ping P Zhu Guangjun G Wang Donglian D Zhu Hongguo H Chen Shiyong S Li Jun J Zhao Haihong H Zhu Yi Y Liu Huafen H Xu Jiaqin J Shen Bo B Guo Tiannan T

Cell reports 20211228 3

The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed the proteome and metabolome of urine and serum samples from patients with COVID-19 and healthy controls. Our data show that urinary proteins effectively classify COVID-19 by severity. We detect 197 cytokines and their receptors in urine, but only 124 in serum using TMT-based proteomics. The decrease in urinary ESCRT complex proteins correlates with active SARS-CoV-2 replication. The downregulation of ur ...[more]

PMID: 35026155

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