Proteomics analysis of glioma cells and astrocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Hui Tan
PROVIDER: PXD030760 | iProX | Thu Jan 06 00:00:00 GMT 2022
REPOSITORIES: iProX
Publications
Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma.
Lu Guihong G Wang Xiaojun X Li Feng F Wang Shuang S Zhao Jiawei J Wang Jinyi J Liu Jing J Lyu Chengliang C Ye Peng P Tan Hui H Li Weiping W Ma Guanghui G Wei Wei W
Nature communications 20220721 1
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few treatment options. Here, building on the observation of elevated lactate (LA) in resected GBM, we develop biomimetic therapeutic nanoparticles (NPs) that deliver agents for LA metabolism-based synergistic therapy. Because our self-assembling NPs are encapsulated in membranes derived from glioma cells, they readily penetrate the blood-brain barrier and target GBM through homotypic recognition. After reaching ...[more]
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