Proteomics

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Phosphoprotoemics study on caffeine for 24h


ABSTRACT: Phosphoproteomics study on the HepG2 cells which were treated with 6 doses of caffeine for 24 h

ORGANISM(S): Homo Sapiens

SUBMITTER: Ping Xu  

PROVIDER: PXD031005 | iProX | Mon Jan 17 00:00:00 GMT 2022

REPOSITORIES: iProX

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Using transcriptomics, proteomics and phosphoproteomics as new approach methodology (NAM) to define biological responses for chemical safety assessment.

Li Yuan Y   Zhang Zhenpeng Z   Jiang Songhao S   Xu Feng F   Tulum Liz L   Li Kaixuan K   Liu Shu S   Li Suzhen S   Chang Lei L   Liddell Mark M   Tu Fengjuan F   Gu Xuelan X   Carmichael Paul Lawford PL   White Andrew A   Peng Shuangqing S   Zhang Qiang Q   Li Jin J   Zuo Tao T   Kukic Predrag P   Xu Ping P  

Chemosphere 20221122


Omic-based technologies are of particular interest and importance for hazard identification and health risk characterization of chemicals. Their application in the new approach methodologies (NAMs) anchored on cellular toxicity pathways is based on the premise that any apical health endpoint change must be underpinned by some alterations at the omic levels. In the present study we examined the cellular responses to two chemicals, caffeine and coumarin, by generating and integrating multi-omic da  ...[more]

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